MSC High-Dose Advanced Regenerative Care

Why La Vida Uses 600–700 Million Cells

When MSCs are administered intravenously, a portion of the cells are temporarily retained in the lung microvasculature—a well-documented phenomenon known as the pulmonary first-pass effect. While this effect plays a role in immune regulation, it also means that higher total doses are often required to achieve meaningful systemic results.

At La Vida, 600–700 million MSC dosing may be recommended to:

• Compensate for pulmonary first-pass sequestration
• Deliver a robust paracrine and exosomal signaling response
• Address widespread inflammation and immune dysregulation
• Support neurologic, autoimmune, and degenerative conditions
• Provide sufficient therapeutic intensity for long-standing or refractory disease

These dosing levels reflect international physician-guided protocols and are not routinely available in standard treatment settings.

Conditions Commonly Considered at La Vida

While every treatment plan is fully individualized, higher-dose IV MSC therapy at La Vida is often considered for patients with:

• Advanced autoimmune or inflammatory disorders
• Neuroinflammatory or neurodegenerative conditions
• Systemic inflammatory syndromes
• Multi-joint or whole-body degenerative disease
• Post-viral or immune-mediated chronic conditions
• Limited or short-lived response to lower MSC doses

Final dosing and candidacy are determined exclusively by the treating physician following a comprehensive medical review.

How High-Dose IV MSC Therapy Works

At La Vida, MSC therapy is designed to support the body’s own repair mechanisms rather than replace damaged tissue directly.

MSCs act as powerful biologic signaling cells, releasing:

• Anti-inflammatory cytokines
• Immune-regulating factors
• Growth factors that support tissue repair
• Exosomes that enhance cellular communication

At higher doses, these signaling effects are amplified systemically, making this protocol especially suitable for patients with complex or diffuse disease patterns.

La Vida Infusion & Optimization Protocol

To maximize both safety and effectiveness, La Vida employs enhanced infusion protocols for high-dose IV MSC therapy, which may include:

• Extended infusion times (typically 60–120 minutes)
• Proper dilution volumes for vascular comfort
• Pre-hydration and supportive IV nutrient therapy
• Oxygen or hyperbaric optimization when indicated
• Continuous physician oversight throughout treatment

These measures are designed to optimize cell viability, circulation, and patient comfort while supporting a favorable therapeutic environment.

Safety & Physician Oversight at La Vida

International clinical experience has demonstrated that IV MSC doses approaching or exceeding 700 million cells can be administered safely when proper protocols are followed.

At La Vida, safety is supported by:

• Rigorous cell screening and handling standards
• Careful patient selection and medical clearance
• Controlled infusion rates
• On-site physician supervision

MSCs do not permanently engraft or replicate uncontrollably. Their effects are primarily mediated through temporary immune modulation and regenerative signaling, contributing to a strong safety profile when used responsibly.

Is 600–700M IV Therapy Right for You?

This advanced dosing strategy is typically reserved for patients who:

• Have long-standing, progressive, or refractory conditions
• Require systemic rather than localized regenerative support
• Have not achieved desired outcomes with lower MSC doses
• Are seeking the most comprehensive regenerative approach offered at La Vida

A personalized consultation and physician review are required to determine the most appropriate treatment plan.